Position-sensitive ion detection in precision Penning trap mass spectrometry

Position-sensitive ion detection in precision Penning trap mass spectrometry

A commercial, position-sensitive ion detector was used for the rst time for the time-ofight ion-cyclotron resonance detection technique in Penning trap mass spectrometry. In this work, the characteristics of the detector and its implementation in a Penning trap mass spectrometer will be presented. In addition, simulations and experimental studies concerning the observation of ions ejected from ...

Ramsey method of separated oscillatory fields for high-precision penning trap mass spectrometry.

Ramsey's method of separated oscillatory fields is applied to the excitation of the cyclotron motion of short-lived ions in a Penning trap to improve the precision of their measured mass values. The theoretical description of the extracted ion-cyclotron-resonance line shape is derived and its correctness demonstrated experimentally by measuring the mass of the short-lived 38Ca nuclide with an u...

Quadrupole ion trap mass spectrometry.

A number of other features of ITMS systems that will enhance their ability to analyze biological macromolecules are worth mentioning. As has already been demonstrated for ESI/quadrupole, ESI/magnetic sector, and ESI/FTICR systems, the capability of inducing fragmentation of the ESI-generated multiply charged ions of biological macromolecules in the capillary/skimmer region of the ESI source and...

Sensitive detection of isoglobo and globo series tetraglycosylceramides in human thymus by ion trap mass spectrometry.

Glycosphingolipids serve as ligands for receptors involved in signal transduction and immune recognition, as exemplified by isoglobotrihexosylceramide, an antigenic ligand for T cell receptors. Mechanistic studies on the regulation of isoglobotrihexosylceramide require biochemical measurement of its lysosomal precursor, isoglobotetraglycosylceramide. It remains a challenge to distinguish betwee...

Using AP-MALDI Ion Trap Mass Spectrometry